HAIR TISSUE ENGINEERING 

We produce cell-based materials for medical, cosmetics and industrial  applications.

This enables us to obtain developmental data for the upscale and gene-editing of desired traits (pigmentation, scale up technology and production/feasibility studies) in human applications without the usual restrictions of human clinical trails regulations. 

Our HAIROID IP is the first entirely human, patient derived, hairfollicle as presented in our poster (177) at the WCHR Congress in Barcelona/ Spain in April 2019. With our recent June 2020 PCT conversion we’ve set a benchmark for the development of a feasible therapy, far beyond the usually circulated laboratory scale experiments from scientific groups all around the globe.

With the imminent instruction of an integrated “GT” de-rsiking approach we are more than ever committed to contribute to the ALOPECIA  field. We will work discrete but relentless towards the clinical application and welcome the efforts of various talented scientists, surgeons and industry professionals to overcome this disease with it’s associated severe “comorbidities” such as psychological disorders.

FIG. 1: bioprinted tissue with attached Dermal Papillae cells

 

With the classical TE approach, cells are seeded onto a prefabricated scaffold, typically in conjunction with the delivery of bioactive factors that ensure maintenance of cellular phenotype and appropriate extracellular matrix formation. 

An alternative concept envisions the development of in vitro 3D tissue models, which exhibit functional features of native tissues, for application in an in vitro testing or screening system.

Printing Project 1 2019 NON GMP COMPLIANT:

Image of construct 33 day post bioprinting.  Bioprinted grid structure is clearly visible with hair-follicle aggregates formed within the pore structures. The hair-follicles are inseparably attached. This model serves as an in vitro test system for cosmetics and medical applications furthermore as a platform technology  for various industrial applications.

ADIPOSE TISSUE ENGINEERING:

Adipose tissue (or fat), which resides beneath the dermis of the skin, plays an essential role in maintaining body temperature, storing energy and our appearance. Large wounds e.g. burns and trauma wounds can be adequately closed by applying split or full thickness autografts, however restauration of the adipose tissue is still a challenge.

Furthermore there is an increasing request to perform adipose tissue transplants for cosmetic purposes. Current restoration of adipose tissue relies on removing adipose tissue from one area of the body by liposuction and injecting it into the area required.

The overall aim of this project is to bio-engineer a cell based adipose tissue therapy for cosmetic applications and for transplantation under the dermis of the skin.

IMAGE 3.: Adipose Stromal Cells and Adipocytes merged

We’ve developed a procedure for isolating and preparing cells for restoration of adipose tissue which involves isolating viable adipose derived stromal cells (ASCs) from adipose tissue, amplifying them followed with an option for long term storage, and then differentiating the cells into a mixture of stromal cells and adipocytes. Since this has been achieved, we are developing a means to apply the stromal cell / adipocyte mixture via e.g. an injectable and a medical device scaffold.
IMAGE 4.: Schematics of  Adipose Stromal Cells and Adipocytes product.